Scientist/Senior Scientist, Computational Biology

San Diego, CA

  • We are seeking a creative, highly motivated, responsible, and dynamic scientist to join our R&D division to contribute to high-impact and fast-paced research and drug discovery. 
  • This position is a full-time position in the company’s San Diego headquarters. 

Specific Responsibilities

  • Contribute to the identification and characterization of novel targets and mechanisms in cancer, exploring how our portfolio of compounds may be leveraged as cancer therapeutics
  • Contribute to the application of leading-edge computational technologies for accelerated target evaluation and provide actionable hypotheses for chemical mechanism of action
  • Support generation and analysis of various types of omics data for hypothesis generation and testing to enable novel target discovery, patient selection strategies, and resistance mechanisms
  • Lead multi-omics integration, biological network modeling, biostatistics and systems approaches to drug discovery
  • Interact routinely with Biosplice’s Biology, Chemistry and Bioinformatics teams to integrate knowledge and develop an understanding of complex biological systems; assist these teams in designing experiments to further our understanding of tumor biology and actions of our tool compounds.
  • Engage in data analysis, presenting results, and working collaboratively with others to achieve objectives and timelines
  • Assisting in the preparation of internal and external presentations (oral, posters, and publications)

Requirements

  • Ph.D. in Biological Sciences, Bioinformatics or related field, with 0+ years experience in industry or post-doctoral research, including at least 3+ years of hands-on experience working with various types of omics data
  • Extensive knowledge and experience in human genetics, functional genomics and cancer biology
  • Expertise in standard omics platforms and single cell sequencing technologies (RNAseq, WGS, ChipSeq, ATACseq, TMT, CRISPR)
  • 2+ years of experience coding in R and implementing standard R packages widely used in bioinformatics/computational biology workflows
  • Experience with shell scripting
  • Broad knowledge of Cellular Biology, Molecular Biology, Biochemistry, assay development.
  • Proven track record of scientific contributions in computational biology, functional genomics and drug discovery as evidenced by quality and quantity of publications and presentations.
  • Proven ability to collaborate in a team environment and work independently.
  • Excellent oral and written communication skills. Outstanding organizational and critical thinking skills.
  • Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Level will be commensurate with experience

Preferred Requirements

  • Experience with cancer biology and the application of omics techniques in this context (especially RNA-seq and single-cell techniques)
  • At least some wet-lab experience or familiarity with wet-lab techniques is strongly preferred, in particular standard molecular biology techniques and with cell culture and cell-based assays
  • Computational biology experience as part of post-doctoral research or in industry

Please submit your resume or additional inquiries to apply@biosplice.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.