Scientist/Senior Scientist, Computational Biology

San Diego, CA

  • Biosplice is seeking a creative, highly motivated, responsible, and dynamic scientist to join our R&D division to contribute to high-impact and fast-paced research and drug discovery.
  • This is a full-time position in the company’s San Diego headquarters. 

Specific Responsibilities

  • Contribute to the identification and characterization of novel targets and mechanisms of tissue degeneration and disease (including, but not limited, to oncology, neuroscience, musculoskeletal, immunology, etc.)
  • Contribute to the application of leading-edge computational technologies for accelerated target evaluation and provide actionable hypotheses for chemical mechanism of action
  • Support generation and analysis of various types of omics data for hypothesis generation and testing to enable novel target discovery, drug mechanisms of action, patient selection strategies, and resistance mechanisms
  • Lead multi-omics integration, biological network modeling, biostatistics and systems approaches to drug discovery
  • Interact routinely with Biosplice’s Biology, Chemistry and Bioinformatics teams to integrate knowledge and develop an understanding of complex biological systems
  • Engage in data analysis, presenting results, and working collaboratively with others to achieve objectives and timelines
  • Analyzing and documenting experimental data in electronic notebooks in a timely and accurate manner in accordance with the company rules
  • Presenting scientific data to colleagues and assisting in the preparation of internal and external presentations (oral, posters, and publications)

Requirements

  • Ph.D. in Biological Sciences, Bioinformatics or related field with at least 0+ years of post-doctoral training and/or 0+ years of pharmaceutical/ biotechnology industry experience.
  • Extensive knowledge and experience in human genetics, functional genomics, cancer biology and deep molecular phenotypic profiling for drug discovery.
  • Deep expertise in bioinformatics, biostatistics, and computational techniques.
  • Expertise in standard omics platforms and single cell sequencing technologies (RNAseq, WGS, ChipSeq, ATACseq, TMT, CRISPR)
  • Broad knowledge of Cellular Biology, Molecular Biology, Biochemistry, and assay development.
  • Deep experience working with bioinformaticians, biologists and chemists.
  • Proven track record of scientific contributions in computational biology, functional genomics and drug discovery as evidenced by quality and quantity of publications and presentations.
  • Proven ability to collaborate in a team environment and work independently.
  • Excellent oral and written communication skills. Outstanding organizational and critical thinking skills.
  • Ability to provide novel creative solutions to challenging problems. Desire to learn and tackle new challenges and initiatives.
  • Level will be commensurate with experience

Please submit your resume or additional inquiries to apply@biosplice.com. Please include the complete title of the position for which you are applying in the subject line of your email. Emails that do not include this information will be disregarded. NO PHONE CALLS PLEASE.