Biosplice Therapeutics has widely presented its science and data. Please choose the area of interest below to view a sampling of these publications.

Rheumatology and Therapy | June 08, 2021

  • Individual Participant Symptom Responses to Intra-Articular Lorecivivint in Knee Osteoarthritis: Post Hoc Analysis of a Phase 2B Trial

    Rheumatology and Therapy. doi: 10.1007/s40744-021-00316-w

    Jeyanesh R. S. Tambiah, Sarah Kennedy, Christopher J. Swearingen, Ismail Simsek, Yusuf Yazici, Jack Farr & Philip G. Conaghan

ClinicoEconomics and Outcomes Research | May 21, 2021

  • Real-World Health Care Resource Utilization and Costs Among US Patients with Knee Osteoarthritis Compared with Controls

    ClinicoEconomics and Outcomes Research. doi: 10.2147/CEOR.S302289

    Angela V Bedenbaugh, Machaon Bonafede, Elizabeth H Marchlewicz, Vinson Lee, Jeyanesh Tambiah

Osteoarthritis Research Society International (OARSI) Virtual World Congress | April 29 - May 03, 2021

Osteoarthritis Research Society International (OARSI) Virtual World Congress | April 29 - May 03, 2021

Osteoarthritis and Cartilage | February 12, 2021

  • A Phase 2b Randomized Trial of Lorecivivint, a Novel Intra-articular CLK2/DYRK1A Inhibitor and Wnt Pathway Modulator for Knee Osteoarthritis

    Osteoarthritis and Cartilage. doi: 10.1016/j.joca.2021.02.004

    Yusuf Yazici, MD, Timothy E. McAlindon, MD, MPH, Allan Gibofsky, MD, JD, Nancy E. Lane, MD, Christian Lattermann, MD, Nebojsa Skrepnik, MD, PhD, Christopher J. Swearingen, PhD, Ismail Simsek, MD, Heli Ghandehari, MS, Anita DiFrancesco, BS, BA, Jamielle Gibbs, MPH, Jeyanesh Tambiah, MD, Marc C. Hochberg, MD, MPH

Journal of Orthopaedic Research | October 26, 2020

  • SM04755, a small‐molecule inhibitor of the Wnt pathway, as a potential topical treatment for tendinopathy

    Journal of Orthopaedic Research. doi: 10.1002/jor.24898

    Vishal Deshmukh, Tim Seo, Alyssa L. O'Green, Maureen Ibanez, Brian Hofilena, Sunil KC, Joshua Stewart, Luis Dellamary, Kevin Chiu, Abdullah Ghias, Charlene Barroga, Sarah Kennedy, Jeyanesh Tambiah, John Hood, Yusuf Yazici

Journal of Medical Economics | August 13, 2020

  • Health care resource utilization and burden of disease in a U.S. Medicare population with a principal diagnosis of osteoarthritis of the knee

    Journal of Medical Economics. doi: 10.1080/13696998.2020.1801453

    Fang Chen, Wenqing Su, Angela V. Bedenbaugh & Arman Oruc

Arthritis & Rheumatology | May 20, 2020

  • Lorecivivint, a Novel Intra‐articular CLK/DYRK1A Inhibitor and Wnt Pathway Modulator for Treatment of Knee Osteoarthritis: A Phase 2 Randomized Trial

    Arthritis & Rheumatology. doi: 10.1002/art.41315

    Yusuf Yazici, Timothy E. McAlindon, Allan Gibofsky, Nancy E. Lane, Daniel Clauw, Morgan Jones, John Bergfeld, Christopher J. Swearingen, Anita DiFrancesco, Ismail Simsek, Jeyanesh Tambiah, Marc C. Hochberg

Advances in Alzheimer’s and Parkinson’s Disease Therapies (AD/PD) Focus Meeting 2020 | April 02 - 05, 2020

Cartilage Regeneration & Joint Preservation Society (ICRS) World Congress | October 05 - 08, 2019

Cartilage Regeneration & Joint Preservation Society (ICRS) World Congress | October 05 - 08, 2019

Cancer Letters | September 24, 2019

  • The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models

    Cancer Letters. doi:10.1016/j.canlet.2019.09.009

    Betty Y.Tam, Kevin Chiu, Heekyung Chung, Carine Bossard, John Duc Nguyen, Emily Creger, Brian W. Eastman, Chi Ching Mak, Maureen Ibanez, Abdullah Ghias, Joseph Cahiwat, Long Do, Shawn Cho, Jackie Nguyen, Vishal Deshmukh, Josh Stewart, Chiao-wen Chen, Charlene Barroga, Luis Dellamary, Sunil K. KC, Timothy J. Phalen, John Hood, Steven Cha, Yusuf Yazici

Gordon Research Conference (GRC) - Wnt Signaling Networks in Development, Disease and Regeneration | August 11 - 16, 2019

Aging Cell | July 03, 2019

  • Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease

    Aging Cell. doi: 10.1111/acel.13000

    Benoît Melchior, Gopi Kumar Mittapalli, Carolyn Lai, Karen Duong‐Polk, Joshua Stewart, Bora Güner, Brian Hofilena, Amanda Tjitro, Scott D. Anderson, David S. Herman, Luis Dellamary, Christopher J. Swearingen, K.C. Sunil, Yusuf Yazici

Osteoarthritis and Cartilage | May 24, 2019

  • Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

    Osteoarthritis and Cartilage. doi: 10.1016/j.joca.2019.05.006

    V. Deshmukh, A.L. O'Green, C. Bossard, T. Seo, L. Lamangan, M. Ibanez, A. Ghias, C. Lai, L. Do, S. Cho, J. Cahiwat, K. Chiu, M. Pedraza, S. Anderson, R. Harris, L. Dellamary, S. KC, C. Barroga, B. Melchior, B. Tam, S. Kennedy, J. Tambiah, J. Hood, Y. Yazici

International Society for Pharmaeconomics and Outcomes Research (ISPOR) | May 18 - 22, 2019

International Dermatology and Cosmetology Congress (INDERCOS) | March 27 - 30, 2019

International Cartilage Regeneration & Joint Preservation Society (ICRS) Summit | January 17 - 18, 2019

World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases | April 19 - 22, 2018

World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases | April 19 - 22, 2018

Osteoarthritis and Cartilage | September 15, 2017

Osteoarthritis and Cartilage | July 13, 2017

  • A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study

    Osteoarthritis and Cartilage, 25(10), 1598-1606. doi: 10.1016/j.joca.2017.07.006

    Y. Yazici, T.E. McAlindon, R. Fleischmann, A. Gibofsky, N.E. Lane, A.J. Kivitz, N. Skrepnik, E. Armas, C.J. Swearingen, A. DiFrancesco, J.R.S. Tambiah, J. Hood, M.C. Hochberg

International Cartilage Repair Society Heritage Summit | June 29 - July 01, 2017

International Society for Pharmacoeconomics and Outcomes (ISPOR) | May 20 - 24, 2017

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